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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
A high-fat meal is known to cause a higher chance of side effects. While using a high-fat meal, avoid consuming grapefruit or grapefruit juice while using Cialis.
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    Cautions:

    • Cialis is used for the treatment of angina, heart problems, and high blood pressure
    • Use with caution in individuals with certain liver disease or a history of heart attack or stroke
    • Consult your doctor before taking other medications, including prescription drugs
    • Do not take Cialis if you are taking:
    • Tadalafil (e.g., sildenafil) or tadalafil with sildenafil (e.g., vardenafil)
    • Sildenafil (e.g.

    Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

    You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

    There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

    • Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

    • Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

    for chest pain or use Rectogesic ointment?

    • Nicorandil (Ikorel), used to treat angina

    • Cimetidine, used to treat stomach or duodenal (peptic) ulcers

    • Theophylline, used to treat asthma

    • Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

    • Anti-fungals such as itraconazole and ketoconazole

    • Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

    • Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

    • Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

    • Recreational drugs:- amyl nitrate (poppers)

    If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

    Read available consultation questionnaire

    What is Tadalafil?

    Tadalafil is a prescription medication that is used to treat erectile dysfunction (ED) in men.

    Tadalafil is also used to help in the prevention of suicidal thoughts and rates in some young people.

    Tadalafil is only considered as a medicine when it is not used in the usual way to relieve any other symptoms.

    How does Tadalafil work?

    Tadalafil is an anti-androgen medication which works by increasing blood flow to the penis during sexual stimulation. This increases the strength of the erections made by Tadalafil.

    During sexual stimulation Tadalafil has the effect of relaxing the muscles in the penis and increasing blood flow.

    The use of Tadalafil is not recommended if taking “ phosphodiesterase type 5 (PDE5) inhibitors, or PDE5 inhibitors, in the last 6 months of prior to sexual activity,” as it may cause an erection that may become unplanned.

    What should you know about Tadalafil before you take Tadalafil?

    You should not take Tadalafil if you are newlywed or have had a heart attack or stroke within the last 6 months.

    When can I take Tadalafil?

    You should not take Tadalafil if you are taking:

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    You are required to have a short medical consultation questionnaire with a doctor of any health care providers interest including men’s health medicine specialists

    Some health care providers may have medical-relatedaky pointsenthe questionnaire

    and will explain the reasons for the medical questionnaire’s absence.

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    An erection occurs when a man is sexually aroused.Cialisis a prescribed medication that works by allowing the blood vessels in the penis to relax, helping to achieve and maintain an erection.

    The recommended starting dose of Cialis is 10 mg, taken about 30 minutes before sexual activity. However, other men may increase the dose to 20 mg or lowered the dose to 5 mg, depending on how you responded to the medication. It is important to take Cialis exactly as directed by the healthcare provider, and not to take more or less than the prescribed amount.

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    FAQ

    Q1: What is Cialis used for?Cialis is used to treat erectile dysfunction (ED) and varicocellosis (the enlargement of the prostate gland in men) by increasing blood flow to the penis.

    Q2: How does Cialis work?Cialis and Viagra work in similar ways, and can be purchased by men who have ED or varicocellosis by using Cialis or Viagra.

    Q3: Can Cialis help with ED?Cialis can help with ED in some men, but not in others.

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